San Francisco 49ers vs Arizona Cardinals
Sep 27, 2026, 8:05 PM UTC
FTSan Francisco 49ers 36 - 30 Arizona Cardinals
Team Strength Comparison
Match Analysis
The ratings paint an absolutely one-sided picture here. San Francisco leads overall power 81 to 29, their defense is 48 points clear at 93 to 45, and they've got a 29-point edge on offense too. The 49ers are also way ahead on dominance at 84 to 38. Arizona's got almost nothing working in their favor in the quality ratings—just a small consistency advantage and a bit more drama, which isn't exactly what you want when you're this outgunned. I'd say the talent disparity is almost staggering. What makes this interesting, though, is that the market and the ratings actually agree for once. Bookmakers are offering 1.24 on San Francisco and 4.25 on Arizona, which translates to 77 percent for the hosts and 23 percent for the visitors—and that lines up perfectly with how much better the 49ers grade out. The head-to-head record adds some texture: Arizona's actually got the edge across all 20 meetings, leading 11 to 9, but in the last five matchups the 49ers have flipped the script, winning three of five. I notice San Francisco's recently been solid both at home and away, sitting at three wins from four in each split. Arizona, meanwhile, is in real trouble—they're one win from five across their last five overall, and they haven't won at home in their last three matches. The 49ers' consistency rating sits at just 20, but Arizona's only at 38, so neither team's been particularly steady. Still, the gap between these two teams is genuinely enormous.
A descriptive read of our own ratings against the market — not a prediction.
Metric by metric
San Francisco 49ers · Arizona Cardinals — our 0-100 ratings, side by side
Season trends
up to 16 seasons, both teams
Archived Sep 27, 2026, 07:15 PM UTC
Odds Analysis & Market Prediction
With each bookmaker's margin removed, the market makes San Francisco 49ers the favourite at 76%. 11 of 11 bookmakers agree.
Fair win probability
Average bookmaker margin 4.3%.
Pre-Match Odds Comparison · San Francisco 49ers vs Arizona Cardinals
| Book | Home | Away |
|---|---|---|
| DraftKings | 1.25 | 4.10 |
| Caesars | 1.26 | 4.00 |
| BetUS | 1.26 | 4.05 |
| FanDuel | 1.25 | 4.15 |
| BetRivers | 1.22 | 4.35 |
| LowVig.ag | 1.26 | 4.03 |
| BetOnline.ag | 1.26 | 4.03 |
| MyBookie.ag | 1.27 | 4.02 |
| BetMGM | 1.27 | 4.00 |
| Bovada | 1.26 | 3.90 |
| Fanatics | 1.27 | 3.90 |
Moneyline captured before kickoff — historical reference only. 18+
Head-to-Head Record
| Week 11 · 2025 | 2025-11-16 | Arizona Cardinals 22-41 San Francisco 49ers | W |
| Week 3 · 2025 | 2025-09-21 | San Francisco 49ers 16-15 Arizona Cardinals | W |
| Week 18 · 2024 | 2025-01-05 | Arizona Cardinals 47-24 San Francisco 49ers | L |
| Week 5 · 2024 | 2024-10-06 | San Francisco 49ers 23-24 Arizona Cardinals | L |
| Week 15 · 2023 | 2023-12-17 | Arizona Cardinals 29-45 San Francisco 49ers | W |
| Week 4 · 2023 | 2023-10-01 | San Francisco 49ers 35-16 Arizona Cardinals | W |
| Week 18 · 2022 | 2023-01-08 | San Francisco 49ers 38-13 Arizona Cardinals | W |
| Week 11 · 2022 | 2022-11-22 | Arizona Cardinals 10-38 San Francisco 49ers | W |
| Week 9 · 2021 | 2021-11-07 | San Francisco 49ers 17-31 Arizona Cardinals | L |
| Week 5 · 2021 | 2021-10-10 | Arizona Cardinals 17-10 San Francisco 49ers | L |
| — · 2020 | 2020-12-26 | Arizona Cardinals 12-20 San Francisco 49ers | W |
| — · 2020 | 2020-09-13 | San Francisco 49ers 20-24 Arizona Cardinals | L |
| — · 2019 | 2019-11-17 | San Francisco 49ers 36-26 Arizona Cardinals | W |
| — · 2019 | 2019-10-31 | Arizona Cardinals 25-28 San Francisco 49ers | W |
| — · 2018 | 2018-10-28 | Arizona Cardinals 18-15 San Francisco 49ers | L |
| — · 2018 | 2018-10-07 | San Francisco 49ers 18-28 Arizona Cardinals | L |
| — · 2017 | 2017-11-05 | San Francisco 49ers 10-20 Arizona Cardinals | L |
| — · 2017 | 2017-10-01 | Arizona Cardinals 18-15 San Francisco 49ers | L |
| — · 2016 | 2016-11-13 | Arizona Cardinals 23-20 San Francisco 49ers | L |
| — · 2016 | 2016-10-07 | San Francisco 49ers 21-33 Arizona Cardinals | L |
San Francisco 49ers — Recent Form — Last Games
- 2026-09-20San Francisco 49ers vs Miami Dolphins 35-13
- 2026-09-11Los Angeles Rams vs San Francisco 49ers 7-27
- 2026-01-18Seattle Seahawks vs San Francisco 49ers 41-6
- 2026-01-11Philadelphia Eagles vs San Francisco 49ers 19-23
- 2026-01-04San Francisco 49ers vs Seattle Seahawks 3-13
- 2025-12-29San Francisco 49ers vs Chicago Bears 42-38
- 2025-12-23Indianapolis Colts vs San Francisco 49ers 27-48
- 2025-12-14San Francisco 49ers vs Tennessee Titans 37-24
Arizona Cardinals — Recent Form — Last Games
- 2026-09-20Arizona Cardinals vs Seattle Seahawks 7-31
- 2026-09-13Los Angeles Chargers vs Arizona Cardinals 14-26
- 2026-01-04Los Angeles Rams vs Arizona Cardinals 37-20
- 2025-12-28Cincinnati Bengals vs Arizona Cardinals 37-14
- 2025-12-21Arizona Cardinals vs Atlanta Falcons 19-26
- 2025-12-14Houston Texans vs Arizona Cardinals 40-20
- 2025-12-07Arizona Cardinals vs Los Angeles Rams 17-45
- 2025-11-30Tampa Bay Buccaneers vs Arizona Cardinals 20-17